IHHT therapy – When cells get out of breath<\/h2><\/div>![](\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%2737%27%20height%3D%2740%27%20viewBox%3D%270%200%2037%2040%27%3E%3Crect%20width%3D%2737%27%20height%3D%2740%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" "\\"Origin")
<\/span><\/div>Oxygen is absolutely vital. So is the body’s ability to perceive and react to fluctuations in oxygen levels. The 2019 Nobel Nobel Prize for Medicine<\/a><\/strong> in 2019, William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza have uncovered how cells perceive oxygen availability. With their work, they created the basis for our understanding of how oxygen influences our cell metabolism and physiological functions. <\/p>\nThe <\/span>IHHT therapy<\/strong> (interval hypoxia-hyperoxia therapy) makes use of precisely these groundbreaking findings. Like simulated altitude training, which we otherwise only know from high-performance sport, it triggers controlled fluctuations in oxygen levels in order to achieve targeted adaptation and activation of the mitochondria. <\/span><\/p>\nIn our practice, ORIGIN HEALTH<\/a> in Basel, we use IHHT therapy to improve mitochondrial performance, support regeneration processes and promote general well-being.<\/strong><\/p>\n<\/div><\/div><\/div>OVERVIEW<\/strong><\/div><\/div>- IHHT therapy \u2013 When cells get out of breath<\/a>
- IHHT Therapy & Hormesis<\/a><\/li>
- Longevity effects of IHHT therapy<\/a><\/li><\/ul><\/li>
- Mitochondria as the central target structure of IHHT therapy<\/a>
- Advantages of IHHT therapy<\/a><\/li>
- <\/span>Increase in mitochondrial performance<\/span><\/span><\/a><\/li>
- <\/span>Regeneration and performance<\/span><\/span><\/a><\/li>
- <\/span>Support of the metabolism<\/span><\/span><\/a><\/li>
- <\/span>Vascular and cardiovascular training<\/span><\/span><\/a><\/li>
- <\/span>Reduction of inflammatory processes<\/span><\/span><\/a><\/li>
- When does IHHT therapy make sense?<\/a><\/li>
- IHHT at Origin Health in Basel: How the therapy works<\/a><\/li>
- IHHT therapy in Basel<\/a><\/li><\/ul><\/li>
- FAQ ON IHHT THERAPY<\/a>
- <\/span>How often should I undergo IHHT therapy?<\/span><\/span><\/a><\/li>
- <\/span>What side effects can occur with IHHT therapy?<\/span><\/span><\/a><\/li>
- <\/span>How long does an IHHT session last?<\/span><\/span><\/a><\/li>
- <\/span>When will I feel the first successes?<\/span><\/span><\/a><\/li><\/ul><\/li><\/ul><\/div><\/div><\/div><\/div>
![\"IHHT](\"https:\/\/originhealth.ch\/wp-content\/uploads\/2025\/02\/IHHT_Basel_Schweiz.jpg\" "\\"Swiss")
<\/span><\/div><\/div><\/div><\/div><\/div>IHHT Therapy & Hormesis<\/p><\/h3><\/div>The fact that a controlled reduction in oxygen levels can benefit the body seems contradictory at first. The effect of hypoxia – i.e. a short-term reduction in the oxygen content in the air we breathe – can be perfectly explained by the principle of hormesis<\/b>. In Longevity Medicine, hormesis is the positive reaction of an organism to a mild, controlled stress stimulus such as cold, heat, fasting or hypoxia. While prolonged stress or an extreme lack of oxygen can lead to damage, mild or temporary hypoxia acts like a training stimulus on your organism. <\/p>\nWhy less oxygen is sometimes “more”<\/h4>\n
The question of whether temporarily reduced oxygen levels (hypoxia) really benefit the body may seem paradoxical at first glance. However, it has actually been shown that mild hypoxia in controlled doses can have remarkable effects: <\/p>\n<\/div>
- <\/i><\/span>\n
Activation of cellular adaptation processes:<\/strong>
The organism reacts to a lack of oxygen by increasing the production of certain proteins (e.g. HIF factors), remodeling mitochondria and improving oxygen utilization.<\/p>\n<\/div><\/li>- <\/i><\/span>\n
Hormetic effect:<\/strong>
A mild stress stimulus such as cold, heat, fasting or even hypoxia can promote the body’s own protective and repair mechanisms – comparable to a training effect – so that the cells become more resistant in the long term.<\/p>\n<\/div><\/li><\/ul><\/div><\/div><\/div><\/div>Longevity effects of IHHT therapy<\/h3><\/div>A study published in May 2023 (“Hypoxia Extends Lifespan and Neurological Function in a Mouse Model of Aging”)<\/a><\/strong> was able to prove that a continuous reduction in oxygen levels in genetically pre-stressed mice led to a significant extension of life and improved neurological function. Even if these laboratory findings cannot be fully transferred to humans, they nevertheless draw attention to the potential of “oxygen reduction” as a longevity measure. longevity measure<\/a><\/strong>. <\/p>\nIHHT (interval hypoxia-hyperoxia therapy) does not rely on permanent hypoxia, but on short, alternating phases of reduced and increased oxygen levels. This recurring alternation opens up new opportunities to “train” the body in a targeted manner without risking a permanent undersupply. In addition, not everyone is given the option of only staying at high altitudes from now on.<\/p>\n<\/div><\/div><\/div><\/div><\/div>
IHHT therapy is a wonderful way to integrate the effects of hypoxia into your own longevity program at ORIGIN HEALTH. Train your cells like a top athlete – but in a relaxed, seated position! <\/p>\n<\/div>
Book an appointment now<\/span><\/a><\/div><\/div><\/div><\/div><\/div>![\"Vital](\"https:\/\/originhealth.ch\/wp-content\/uploads\/2025\/03\/IHHT_Biohacking.jpg\" "\\"Woman")
<\/span><\/div><\/div><\/div><\/div><\/div>The mode of action<\/p>\n<\/div>
Mitochondria as the central target structure of IHHT therapy<\/h2><\/div>Regardless of whether we are young or old, our cells depend to a large extent on stable energy production. The mitochondria, often referred to as the “power plants of the cells”, are responsible for converting food into adenosine triphosphate (ATP). With increasing age or chronic stress, mitochondria often become imbalanced, which can contribute to energy deficiency, increased susceptibility to oxidative damage and accelerated ageing processes. <\/p>\n
The controlled hypoxia and hyperoxia intervals of IHHT therapy act like a kind of “fitness program” at cellular level. In phases with less oxygen, mitochondria are required to work more efficiently and replace any damaged parts. During the subsequent hyperoxia, the cells can regenerate and relax with plenty of oxygen. This cyclical stress activates numerous metabolic and antioxidant protective mechanisms that are often less stressed under “normal” conditions. <\/p>\n<\/div>
Advantages of IHHT therapy<\/h3><\/div><\/i><\/i><\/span>Increase in mitochondrial performance<\/span><\/a><\/h3><\/div>The cyclical oxygen fluctuations promote the renewal and performance of the mitochondria and thus the general energy metabolism.<\/div><\/div><\/div><\/i><\/i><\/span>Regeneration and performance<\/span><\/a><\/h3><\/div>Improved cell and mitochondrial function accelerates recovery processes (e.g. after illness, surgery or intensive training).<\/div><\/div><\/div><\/i><\/i><\/span>Support of the metabolism<\/span><\/a><\/h3><\/div>\nIHHT therapy can help to regulate sugar and fat metabolism and improve insulin sensitivity.<\/p>\n
Read more <\/a><\/p>\n<\/div><\/div><\/div><\/i><\/i><\/span>Vascular and cardiovascular training<\/span><\/a><\/h3><\/div>\nThe targeted variation of the oxygen partial pressure has a positive training effect on the cardiovascular system.<\/p>\n<\/div><\/div><\/div>
<\/i><\/i><\/span>Reduction of inflammatory processes<\/span><\/a><\/h3><\/div>\nStudies<\/a> indicate that a regulated lack of oxygen (hypoxia) can help to mitigate systemic inflammatory processes.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>Diabetes mellitus<\/h4>\n
Why are some people more prone to diabetes than others? Genes certainly play a role, but your lifestyle is far more decisive. The actual onset of the disease is often preceded by a process lasting years, during which the metabolism slowly loses its balance. This is precisely where IHHT therapy comes in: it supports you in slowing down or even reversing these gradual undesirable developments. It is important that you use IHHT as part of a holistic concept – accompanied by functional medicine<\/a><\/strong> – and also take care of factors such as diet, exercise and stress reduction. This is because no therapy alone can combat an unbalanced diet, lack of exercise and long-term stress. However, in combination with other measures, IHHT offers an underused but extremely effective way of strengthening your health in the long term. <\/p>\n <\/p>\n<\/div><\/div><\/div>
Burnout and stress sensitivity<\/h4>\n
Many of us feel as if we are constantly running at high speed – without ever really coming to rest. If this state continues, burnout can be imminent: the cells “burn out” and this is noticeable both physically and mentally. In such a phase, your own reserves are usually no longer sufficient to recover. We offer you professional support – including in the form of IHHT therapy – to gradually restore your energy levels and balance your autonomic nervous system. This enables you to switch more easily between activity and relaxation. Deep, lasting regeneration becomes possible again. <\/p>\n<\/div><\/div><\/div>
Losing weight with IHHT therapy<\/h4>\n
IHHT therapy optimizes numerous biochemical and physical processes that are required for successful weight loss. For example, the formation of oxygen carriers is stimulated so that the oxygen-consuming fat burning process in the mitochondria can run more smoothly. At the same time, the mitochondria are “rejuvenated” by the IHHT effect so that they convert fats even more efficiently. The therapy also increases insulin sensitivity, which specifically counteracts the “mast effect” of the hormone (insulin closes the fat cells and slows down the breakdown of fat). <\/p>\n<\/div><\/div><\/div><\/div><\/div>
![](\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272200%27%20height%3D%271237%27%20viewBox%3D%270%200%202200%201237%27%3E%3Crect%20width%3D%272200%27%20height%3D%271237%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\")
<\/div><\/div>Breathe in. Breathe out. Feel better!<\/p>\n<\/div>
When does IHHT therapy make sense?<\/h3><\/div><\/div><\/div>IHHT is used in many areas, for example:<\/p>\n
\n- For lack of energy, burnout symptoms or general exhaustion<\/li>\n
- For weight loss and metabolic disorders (e.g. diabetes, insulin resistance)<\/li>\n
- As a supplementary measure for cardiovascular problems or high blood pressure<\/li>\n
- For the consequences of stress as well as sleep and regeneration disorders<\/li>\n
- Accompanying sports to improve endurance and performance<\/li>\n<\/ul>\n
The therapy is particularly helpful if it is embedded in a holistic concept for health and longevity, as is the case with us.<\/p>\n<\/div><\/div><\/div><\/div><\/div>
<\/span><\/div><\/div><\/div>IHHT at Origin Health in Basel: How the therapy works<\/h3><\/div><\/div><\/div><\/div><\/div>
![](\"https:\/\/originhealth.ch\/wp-content\/uploads\/2025\/02\/origin-health_logo.svg\" "\\"Origin"){kind=logo}
<\/span><\/div>Oxygen is absolutely vital. So is the body’s ability to perceive and react to fluctuations in oxygen levels. The 2019 Nobel Nobel Prize for Medicine<\/a><\/strong> in 2019, William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza have uncovered how cells perceive oxygen availability. With their work, they created the basis for our understanding of how oxygen influences our cell metabolism and physiological functions. <\/p>\n The <\/span>IHHT therapy<\/strong> (interval hypoxia-hyperoxia therapy) makes use of precisely these groundbreaking findings. Like simulated altitude training, which we otherwise only know from high-performance sport, it triggers controlled fluctuations in oxygen levels in order to achieve targeted adaptation and activation of the mitochondria. <\/span><\/p>\n In our practice, ORIGIN HEALTH<\/a> in Basel, we use IHHT therapy to improve mitochondrial performance, support regeneration processes and promote general well-being.<\/strong><\/p>\n<\/div><\/div><\/div> The fact that a controlled reduction in oxygen levels can benefit the body seems contradictory at first. The effect of hypoxia – i.e. a short-term reduction in the oxygen content in the air we breathe – can be perfectly explained by the principle of hormesis<\/b>. In Longevity Medicine, hormesis is the positive reaction of an organism to a mild, controlled stress stimulus such as cold, heat, fasting or hypoxia. While prolonged stress or an extreme lack of oxygen can lead to damage, mild or temporary hypoxia acts like a training stimulus on your organism. <\/p>\n The question of whether temporarily reduced oxygen levels (hypoxia) really benefit the body may seem paradoxical at first glance. However, it has actually been shown that mild hypoxia in controlled doses can have remarkable effects: <\/p>\n<\/div> Activation of cellular adaptation processes:<\/strong> Hormetic effect:<\/strong> A study published in May 2023 (“Hypoxia Extends Lifespan and Neurological Function in a Mouse Model of Aging”)<\/a><\/strong> was able to prove that a continuous reduction in oxygen levels in genetically pre-stressed mice led to a significant extension of life and improved neurological function. Even if these laboratory findings cannot be fully transferred to humans, they nevertheless draw attention to the potential of “oxygen reduction” as a longevity measure. longevity measure<\/a><\/strong>. <\/p>\n IHHT (interval hypoxia-hyperoxia therapy) does not rely on permanent hypoxia, but on short, alternating phases of reduced and increased oxygen levels. This recurring alternation opens up new opportunities to “train” the body in a targeted manner without risking a permanent undersupply. In addition, not everyone is given the option of only staying at high altitudes from now on.<\/p>\n<\/div><\/div><\/div><\/div><\/div> IHHT therapy is a wonderful way to integrate the effects of hypoxia into your own longevity program at ORIGIN HEALTH. Train your cells like a top athlete – but in a relaxed, seated position! <\/p>\n<\/div> The mode of action<\/p>\n<\/div> Regardless of whether we are young or old, our cells depend to a large extent on stable energy production. The mitochondria, often referred to as the “power plants of the cells”, are responsible for converting food into adenosine triphosphate (ATP). With increasing age or chronic stress, mitochondria often become imbalanced, which can contribute to energy deficiency, increased susceptibility to oxidative damage and accelerated ageing processes. <\/p>\n The controlled hypoxia and hyperoxia intervals of IHHT therapy act like a kind of “fitness program” at cellular level. In phases with less oxygen, mitochondria are required to work more efficiently and replace any damaged parts. During the subsequent hyperoxia, the cells can regenerate and relax with plenty of oxygen. This cyclical stress activates numerous metabolic and antioxidant protective mechanisms that are often less stressed under “normal” conditions. <\/p>\n<\/div> IHHT therapy can help to regulate sugar and fat metabolism and improve insulin sensitivity.<\/p>\n Read more <\/a><\/p>\n<\/div><\/div><\/div> The targeted variation of the oxygen partial pressure has a positive training effect on the cardiovascular system.<\/p>\n<\/div><\/div><\/div> Studies<\/a> indicate that a regulated lack of oxygen (hypoxia) can help to mitigate systemic inflammatory processes.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div> Why are some people more prone to diabetes than others? Genes certainly play a role, but your lifestyle is far more decisive. The actual onset of the disease is often preceded by a process lasting years, during which the metabolism slowly loses its balance. This is precisely where IHHT therapy comes in: it supports you in slowing down or even reversing these gradual undesirable developments. It is important that you use IHHT as part of a holistic concept – accompanied by functional medicine<\/a><\/strong> – and also take care of factors such as diet, exercise and stress reduction. This is because no therapy alone can combat an unbalanced diet, lack of exercise and long-term stress. However, in combination with other measures, IHHT offers an underused but extremely effective way of strengthening your health in the long term. <\/p>\n <\/p>\n<\/div><\/div><\/div> Many of us feel as if we are constantly running at high speed – without ever really coming to rest. If this state continues, burnout can be imminent: the cells “burn out” and this is noticeable both physically and mentally. In such a phase, your own reserves are usually no longer sufficient to recover. We offer you professional support – including in the form of IHHT therapy – to gradually restore your energy levels and balance your autonomic nervous system. This enables you to switch more easily between activity and relaxation. Deep, lasting regeneration becomes possible again. <\/p>\n<\/div><\/div><\/div> IHHT therapy optimizes numerous biochemical and physical processes that are required for successful weight loss. For example, the formation of oxygen carriers is stimulated so that the oxygen-consuming fat burning process in the mitochondria can run more smoothly. At the same time, the mitochondria are “rejuvenated” by the IHHT effect so that they convert fats even more efficiently. The therapy also increases insulin sensitivity, which specifically counteracts the “mast effect” of the hormone (insulin closes the fat cells and slows down the breakdown of fat). <\/p>\n<\/div><\/div><\/div><\/div><\/div> Breathe in. Breathe out. Feel better!<\/p>\n<\/div> IHHT is used in many areas, for example:<\/p>\n The therapy is particularly helpful if it is embedded in a holistic concept for health and longevity, as is the case with us.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/span><\/div><\/div><\/div><\/div><\/div>IHHT Therapy & Hormesis<\/p><\/h3><\/div>
Why less oxygen is sometimes “more”<\/h4>\n
The organism reacts to a lack of oxygen by increasing the production of certain proteins (e.g. HIF factors), remodeling mitochondria and improving oxygen utilization.<\/p>\n<\/div><\/li>
A mild stress stimulus such as cold, heat, fasting or even hypoxia can promote the body’s own protective and repair mechanisms – comparable to a training effect – so that the cells become more resistant in the long term.<\/p>\n<\/div><\/li><\/ul><\/div><\/div><\/div><\/div>Longevity effects of IHHT therapy<\/h3><\/div>
<\/span><\/div><\/div><\/div><\/div><\/div>Mitochondria as the central target structure of IHHT therapy<\/h2><\/div>
Advantages of IHHT therapy<\/h3><\/div>
<\/i><\/i><\/span>Increase in mitochondrial performance<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Regeneration and performance<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Support of the metabolism<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Vascular and cardiovascular training<\/span><\/a><\/h3><\/div>
<\/i><\/i><\/span>Reduction of inflammatory processes<\/span><\/a><\/h3><\/div>
Diabetes mellitus<\/h4>\n
Burnout and stress sensitivity<\/h4>\n
Losing weight with IHHT therapy<\/h4>\n
<\/div><\/div>
When does IHHT therapy make sense?<\/h3><\/div>
\n
IHHT at Origin Health in Basel: How the therapy works<\/h3><\/div><\/div><\/div><\/div><\/div>